This is not new knowledge — bodybuilders are used to warnings about non-medical usage, misuse, and abuse of synthetic anabolic steroids.
So much so that more often than not, those warnings are scoffed at or ignored for any number of reasons.
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Durabolin, also known as Deca-Durabolin or simply Deca, is a form of nandrolone with the decanoate ester attached to it.
Durabolin is a form of nandrolone like the male hormone testosterone.
It provides a number of benefits including anabolic or tissue building, androgenic, enhancing the male characteristics and capabilities, as well as the ability to stimulate red blood cell production (erythropoiesis).
The injection form of nandrolone decanoate, Durabolin and or Deca-Durabolin is a synthetically or lab created variation of the male hormone testosterone and as such provides similar functions and characteristics in regard to capabilities and mechanism of action.
Medically, Durabolin was often indicated in the treatment of anemias caused by inadequate red blood cell production.
It’s also been used to treat a number of growth failures, cancer of the breast, hereditary angioedema, and other conditions.
Its main mechanism of action is that it behaves as an androgen receptor agonist or trigger.
Agonists “trigger” certain responses, actions, and functions and interactions among certain types of cells and their receptors.
Unlike other anabolic steroids, nandrolone resists chemical breakdown into dihydro- testosterone (DHT) through the function of the five-alpha reductase (5? reductase), but rather into a less potent yet effective product known as dihydronandrolone.
Deca-durabolin is available for sale in a variety of forms, mostly powder, commonly produced today in China.
At any rate, Deca-Durabolin is classified as a C18 steroid that provides users with anabolic as well as androgenic properties.
It’s created from alkyl esters of estradiol in a laboratory to become a variation of testosterone with one less carbon found at the 19 position.
Durabolin is moderately potent in regard to its anabolic properties, and relatively mild in androgenic properties. Nevertheless, it can cause a number of estrogenic side effects.
Some bodybuilders prefer Durabolin because its estrogenic side effects are less prevalent than those with other forms of anabolic androgenic steroids or testosterone itself.
Still, the higher the Deca-durabolin dosage, the higher the potential estrogen levels.
Some widespread side effects associated with anabolic androgenic steroids, including some Durabolin and Deca-durabolin side effects are:
In addition to some mild estrogenic effects, Durabolin can also cause some progestational activities, which contribute to side effects that are often close to those of estrogens.
Two of the most prevalent side effects linked with estrogenic and progestational activity include reduction of natural (endogenous) testosterone production as well as an increase potential to store fat.
One of the most prevalent side effects associated with Durabolin is the potential to develop gynecomastia (growth of breast tissue in men). Because of this potential, and other estrogenic like effects, bodybuilders and athletes often combine anti-estrogen and anti-progestational drugs with Durabolin.
This can also increase the potential for side effects associated with disruptions in normal hormone levels and hormone production and secretions.
Durabolin was discontinued in the US, according to the FDA Orange Book , but is still found in other places around the world as well as underground and black-market resources.
Deca-Durabolin is made by combining nandrolone with benzyl alcohol.
Used by athletes and bodybuilders to yield better results at the gym, some reported Deca-durabolin benefits include:
With these positive Deca-durabolin results, a recent study (2014) noted as a negative increases in the potential for increased alcohol desire with the use of Deca-durabolin, also known as nandrolone decanoate. While the study involved Wistar rats , the results can also apply to potential human reaction.
A question under consideration was whether elevated levels of testosterone could increase potential for alcohol desire. This aspect of use requires further study, but it’s interesting nonetheless when considering uses of Deca-durabolin.
Side effects associated with Durabolin are not only related to dose, nor are they due to frequency or dosage-dependent, but can be based on individual reactions to the drug.
Some of the effects of nandrolone decanoate can promote benefits including weight gain and in reducing cachexia or muscle wasting, especially in those diagnosed with HIV/AIDS, as well as chronic illness.
Studies on animals (and some human case reports) note more negative side effects and adverse reactions than benefits.
A 2011 study, “Anabolic steroid- and exercise-induced cardio depressant cytokines and myocardial?1 receptor expression in CD1 mice” reported that intense training, use of anabolic steroids, and sympathetic nervous system stimulation can have severe side effects.
It can contribute to myocardial damage as well as damage to the overall cardiovascular system due to increases in total cholesterol.
Before considering use of Durabolin by itself, in cycles, or when stacking, the drug should be carefully considered by athletes and bodybuilders.
For some, leaning toward steroid alternatives to Durabolin is an option in regard to benefits with reduced side effects and adverse reactions.