It’s no secret that a large number of women (as well as men) turn to over-the-counter supplements, a variety of prescription strength drugs, as well as anabolic steroids and combinations thereof to enhance and accelerate weight loss.
At the other end of the spectrum is found a large group of individuals of both genders using these same drugs to increase physique, endurance, body composition, and athleticism.
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Women most often use Clenbuterol as a diet pill and appetite suppressant, but this was not the original reason it was marketed.
Clenbuterol is a prescription-strength and prescription-only bronchodilator used in the treatment of asthma.
Two different forms are often used interchangeably by bodybuilders:
Because of its popularity in bodybuilding circles, it’s easy to understand why Clenbuterol is often considered a type of anabolic steroid. It’s not.
Clenbuterol, also known as Clenbuterol hydrochloride and clenbuterolum, is actually a sympathomimetic amine.
More specifically, it’s defined as a long acting beta-adrenergic agonist that has the capability of performing sympathomimetic (automatic central nervous system) functions and activities.
The drug binds to beta-2 adrenergic receptors in the smooth muscle tissues of the bronchial tubes and relaxes them, resulting in a greater rate of nervous system stimulation
How does Clenbuterol boost weight loss results in women?
When this binding and activation occurs, it stimulates the release of an enzyme known as adenyl cyclase, which in turn triggers the conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP).
The increased cAMP levels trigger the relaxation of bronchial smooth muscles.
However, the components in Clenbuterol are also effective in stimulating the central nervous system (and the sympathetic nervous system) that can cause increases in heart rate as well as blood pressure because of those adrenergic activities.
While it is not yet completely understood, it has been noted that Clenbuterol may also promote anabolic and anti-catabolic effects.
That’s why Clenbuterol for women is often used for non-medical reasons: weight loss and preservation of lean muscle mass.
Bodybuilders and those wishing to lose weight often combine use of Clenbuterol into their muscle-mass or bulking cycles to encourage fat loss (this weight loss is not extreme, but may be a few pounds) prior to a competition or athletic event.
If Clenbuterol is not an anabolic-androgenic steroid – it impacts the central nervous system, why does it cause reactions similar to those of anabolic-androgenic steroids?
Though not a steroid a hormone, it does have anabolic properties that can increase muscle mass, hence its use by bodybuilders.
The mechanism of action of Clenbuterol is complex and linked to beta2 adrenoreceptor agonist activities on striated skeletal muscle tissues.
It is also perceived to enhance lipolysis (fat burning) through its reactions to adipocyte beta3- adrenoreceptors.
Clenbuterol has a relatively long half-life, meaning its effects lasts in the body for quite a while (between 30 to 35 hours).
Studies have been performed on the benefits of Clenbuterol in medical treatment scenarios with positive results.
The same cannot be said of use of Clenbuterol for women seeking weight loss, bodybuilding, or athletic performance enhancement.
The drug is a bronchodilator, not a muscle enhancer. While the activities of ATP and cAMP trigger similarities of and actions involved in energy metabolism, the ability of Clenbuterol to promote such activity for muscle building, muscle mass gains, and significant strength would require excessively high dosages.
In addition to very little efficacy in regard to weight loss, Clenbuterol can also cause a number of alarming side effects – even for those under the care of a physician.
Clenbuterol has been reported to be cardio toxic.
One published report, “Rhabdomyolysis secondary to Clenbuterol use and exercise,” (2016) described a situation where an individual was using Clenbuterol for muscle mass increases coupled with exercise for several days prior to admission to the hospital with discolored urine.
The discolored urine was an indication that striated muscle had been damaged and broken down, and excreted through urine.
And another: “Acute Clenbuterol overdose resulting in super ventricular tachycardia and atrial fibrillation,” (2007) defines a situation where medical professionals treated a 31-year-old male bodybuilder diagnosed with acute Clenbuterol “intoxication”.
The individual presented with metabolic and cardiac rhythm disturbances (supraventricular tachycardia), palpitations, and shortness of breath.
For bodybuilding purposes, Clenbuterol does not really have much of an effect on an individual who is overweight, but is most effective on those with an already lean physique.
Clenbuterol for women, especially in regard to weight loss, is not an efficient or safe way to achieve weight loss.
Women will find a variety of bodybuilding and supplemental websites that provide dosage recommendations and instructions on how to take Clenbuterol safely for a weight-loss cycle, but results vary.
Any weight-loss must be achieved through reduced calorie intake and increases in exercise levels. No drug, even Clenbuterol for women, will be effective without effort on the part of the user to lose weight.