Deca is used without prescription or medical oversight by athletes and bodybuilders looking to increase muscle mass, size, their physique and body composition, or to enhance athletic performance in regard to speed and endurance.
Before using Deca-Durabolin and or any anabolic androgenic steroid whether it’s prescribed or not, know everything you can about the drug.
This article will discuss Deca Durabolin’s mechanism of action, benefits of use, dosage recommendations, and most importantly, the potential for side effects and adverse reactions. Click here to visit our recommended supplier.
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Deca-Durabolin is a recognized name in bodybuilding circles.
The synthetic anabolic androgenic steroid is known by numerous chemical names including but not limited to:
Deca-Durabolin, regardless of its nickname or brand/generic name can be identified through its molecular formula: C28H44O3.
Nandrolone decanoate/Deca-Durabolin is a form of nandrolone with the decanoate ester attached. As such, it’s defined as an analog of testosterone that, like testosterone, provides anabolic, androgenic, and red blood cell stimulating capabilities.
Anabolic characteristics promote tissue building effects, hence its application for muscle building endeavors. Its androgenic properties promote and maintain male sex characteristics.
Red blood cells are essential in the growth, development, maturation, and lifecycle of cells throughout the body.
Red blood cells transport oxygen and vital nutrients to every cell in the body. Increased oxygenation improves stamina and endurance.
Deca-Durabolin is the injection form of nandrolone decanoate, generally available in 50 mg per milliliter dosage. The synthetic variation of testosterone gives it many similar characteristics and functional capabilities.
Knowing its mechanism of action and how it functions in the body, and most importantly, in regard to how it can provide benefits to bodybuilders, is of main concern to athletes considering use of the drug.
The decanoate attached to nandrolone refers to its ester. Esters have an influence over how fast or slow the drug is absorbed and spread through the body, in addition to potency of the drug over time.
Of course, other factors consider into this dissemination or absorption of a drug depending on the injection method (intramuscular versus subcutaneous) or other methods of application including oral, transdermal, or tropical.
The decanoate ester provides a relatively slow release of the drug from the injection site. For some, effects of nandrolone decanoate/Deca- Durabolin can last for two to three weeks.
Endogenous testosterone and other synthetic anabolic androgenic steroids may provide stronger or more potent anabolic and pathogenic properties within Deca-Durabolin.
Testosterone has high anabolic/androgenic properties, while Deca-Durabolin, though it does provide moderate to strong anabolic properties, is relatively weak in regard to its androgenic properties.
Because of these characteristics, Deca-Durabolin is popular among bodybuilders looking for a safer and “gentler” form of anabolic androgenic steroid.
While Deca-Durabolin may not provide results at the same potency or speed as other anabolic androgenic steroids, it gets the job done without risking extremely strong and sometimes alarming estrogenic or androgenic side effects.
Most bodybuilders look less for information regarding mechanism of action of an anabolic androgenic steroid in the body than how it works in terms of results.
Most are more interested in how fast the drug provides results, dosage recommendations, and potential for stacking or combining with other drugs.
As such, it’s important to know how a drug behaves in the body and why.
Nandrolone decanoate/Deca-Durabolin is classified as a C18 steroid that has both anabolic and androgenic properties.
In molecular form, it’s prepared from an alkyl ester (decanoate) to mimic the effect of testosterone.
That molecular makeup lacks a carbon at the number 19 position. It’s known by two common synonyms: as 19 nor-testosterone decanoate and nandrolone 17? (beta) decanoate.
The drug belongs to the kingdom of organic compounds and lipid-like molecules. Broken down by class, it’s considered a steroid derivative and found among the subclass of steroid esters.
Deca-Durabolin or its generic name nandrolone decanoate, is no longer recommended as a legal, prescription-strength drug for medical treatments in the US. It was deemed to provoke more side effects than benefits, at least in regard to a number of medical treatments.
As a synthetic variation of testosterone, it produced a number of detrimental side effects and adverse reactions as a result of his androgenic properties.
Like other anabolic steroids, Deca-Durabolin has the potential to suppress pituitary gland functions and processes that involve the gonads, such as testicular function and production of endogenous or body-produced testosterone.
In the past, Deca-Durabolin/nandrolone decanoate was often used to manage anemia of renal insufficiency as well as anemias caused by deficiencies in the production of red blood cells, hereditary angioedema, growth failure, Turner Syndrome (a growth disorder most commonly noted in young females), and some cancers of the breast.
The drug is known to increase red cell synthesis, mass, and hemoglobin. These properties attract use by bodybuilders.
Nandrolone does occur naturally (endogenous) in the human body. Its main function is to increase the production of erythropoietin and its excretion through urine.
It is also believed to have an influence on bone marrow, where red and white blood cells are formed. It’s most known for its ability to bind to androgen receptors, even more so than endogenous testosterone.
Because of unmediated actions by the receptor cells, it has a smaller impact on muscle growth than that of endogenous or body-produced testosterone.
The main mechanism of action of nandrolone and its derivatives is that it acts as an agonist or trigger for androgen receptors.
Androgens are hormones that influence male sex characteristics. This activity enables the drug to bind to certain sequences found in chromosomal DNA, influencing transcription of specific genes that in turn result in androgen effects.
Of interest to athletes and bodybuilders is the metabolic action of nandrolone.
While other anabolic steroids are sensitive to five-alpha (5?) reductase, an enzyme involved in aromatization or conversion of testosterone into estrogen, nandrolone is not, and resists conversion into the hydrotestosterone by 5? reductase.
It is however, broken down into a component known as dehydroandrolone.
Dehydroandrolone (molecular formula C20H26O3), also known as dehydroandrolone acetate, is a relatively new product for the hormone and steroid industry.
It’s a powder commonly manufactured in China, a male steroid or steroid powder also known as 17b-Acetyloxy-estra-4, 6-diene-3-one.
As mentioned, nandrolone, as an androgen receptor, behaves as an agonist or trigger. Steroid hormone receptors are components that regulate certain gene expressions and cellular differentiation and proliferation in specific target tissues.
It’s also known as an aromatase inducer, which has oxygen-binding capabilities and is a component of catalyzing aromatic C 18 estrogens from C19 androgens.
The molecular and chemical actions can be quite complicated and lengthy, but individuals interested in deeper research into the molecular formation and mechanism of actions of various anabolic androgenic steroids can find information on medical and scientific websites as well as digging deeper into chemical compounds.
In many cases, Deca-Durabolin results were based on dosage and frequency of dosage. However, the higher the dosage and frequency of injections, the increased risk of side effects and adverse reactions.
Nandrolone decanoate/Deca-Durabolin was recommended as a deep intramuscular injection, preferably into the upper outer quadrant of the gluteus maximus.
Nandrolone decanoate injections are recommended to be inserted at a 90° angle, with a needle long enough to get below the skin and subcutaneous fat layers and into deep muscle tissues.
Individuals injecting anything into the gluteal muscle must take care to avoid the sciatic nerve.
In the treatment of anemia of renal disease, the medically recommended dose for men ranged anywhere between 100 mg and 200 mg weekly.
Women under treatment were recommended dosages that ranged from 50 mg to 100 mg per week. In cases where no improvement in red blood cell synthesis or hemoglobin were noted within six months, the drug was discontinued.
The drug is designed for intra-muscular use only and vials of the drug contain 200 mg per 1 mL of solution.
It’s available in different strengths (50 mg and 100 mg and 200 mg depending on manufacturer) and dosage (solution and liquid) although all are recommended through intramuscular route administration.
Non-medical use by athletes and bodybuilders often involves a higher than recommended dosage.
For example, when averaging recommendations from a number of bodybuilding websites, suggestions for injection ranged 200 mg to 600 mg weekly for men.
Even at such high dosage and when used alone, nandrolone decanoate/Deca-Durabolin doesn’t tend to promote rapid results. Some results are actually lackluster.
For this reason, athletes and bodybuilders often combine use of Deca-Durabolin with other anabolic androgenic steroids.
Some of the most common: Winstrol/Stanozolol, Dianabol or Trenbolone.
These two anabolic androgenic steroids are much stronger (potent) and can drastically accelerate results, but at the same time also increase potential for side effects.
Deca-Durabolin has been discontinued in the US because of its potential to cause a number of serious side effects and its potential ability to damage major organs and interfere with the functions of numerous body systems.
Women are at risk of developing hypercalcemia, and also experience virilizing (masculinizing) effects that include accelerated and non-normal growth of body and facial hair (hirsutism), menstrual irregularities, a deeper voice, and enlargement of the clitoris.
It is warned that at the first signs of virilization, the drug should be discontinued.
However, even in some cases, early discontinuation did/does not prevent irreversible damage in regard to virilizing effects.
While relatively rare when used with prudence, virilization is a common side effect of high and long-term use of anabolic androgenic steroids in women.
Another of the more common side effects associated with the Deca-Durabolin and other anabolic androgenic steroids is edema or fluid retention. Fluid retention can be dangerous for some, especially a person diagnosed with congestive heart failure.
However, the main concern and potential reason for the discontinuation of Deca-Durabolin/nandrolone decanoate was scientific research reporting liver damage – and a specific condition known as Peliosis hepatis.
This is a condition in which normal liver cells are replaced by cysts filled with blood.
The condition was noted first in patients who were receiving anabolic androgenic steroid therapy under the supervision and monitoring of physicians.
In most cases, this condition causes minimal damage and dysfunction, but some individuals did experience liver failure, intra-abdominal hemorrhage, and liver dysfunction.
In addition to the blood-filled cysts, increased potential for the development of liver tumors were also noted among those undergoing anabolic/androgenic steroid therapy.
Again, while the majority of the tumors were benign and disappeared once the drug was discontinued, others developed malignant tumors that proved fatal.
The tumors were noted to develop in or on vascular tissues, increasing the risk for hemorrhage.
In addition, anabolic androgenic steroids like Deca-Durabolin are known to decrease levels of beneficial or “good” cholesterol (high density lipoprotein – HDL) while at the same time increasing “bad” levels of cholesterol (low-density lipoprotein – LDL).
Higher levels of bad cholesterol than good cholesterol can contribute to hardening of the arteries, which narrows blood vessels and can increase the risk of heart attack or stroke.
Can you find specific information regarding scientific or medical based case studies, reports, or clinical trials that definitively define the potential dangers and side effects associated with nandrolone decanoate/Deca-Durabolin?
Yes, both pro and con. Some of the pro:
The cons for use of Deca-Durabolin/nandrolone decanoate far outweigh the potential benefits. A few cases in point:
The bottom line is that certain anabolic androgenic steroids, especially when used outside of medical monitored environments, are often used in high doses and sometimes excessively higher doses than recommended for medical treatments.
Bodybuilders often scoff at the potential for side effects, claiming that “when used responsibly” the drugs don’t tend to cause side effects or adverse reactions.
However, most, if not all of the dosage recommendations for anabolic androgenic steroids provided by bodybuilders, bodybuilding websites and forums are typically higher than medically recommended dosages.
Because of the potential for damaging and often life-threatening side effects, more athletes today are turning to steroid alternatives, which, while they may take longer to produce results, are a lot safer, legal, and don’t tend to cause many of the damaging side effects and organ malfunctions and anomalies associated with prescription strength anabolic androgenic steroids.
Deca-Durabolin may be considered a relatively safe anabolic androgenic steroid, but always take the time to do some research into how it behaves in the body.
Some individuals may be sensitive to some of the mechanisms of action applicable to the Deca-Durabolin/nandrolone decanoate.
The drug is contraindicated for any woman who is pregnant, planning to become pregnant, or nursing. Nandrolone is classified under the pregnancy category X, meaning that it has the potential to cause fetal damage.
It may produce severe adverse reactions in nursing infants if the steroid is excreted in breast milk.
Deca-Durabolin is contraindicated for any male who has been diagnosed with breast cancer or suspected or diagnosed prostate cancer. It is also contraindicated for anyone who has been diagnosed with any liver malfunction, dysfunction, or disease process.
When choosing anabolic androgenic steroids like Deca-Durabolin, it’s not enough to compare the androgenic with the anabolic effects.
Every individual can react differently to any drug, regardless of dosage. Even at low doses, a healthy individual can experience rapid onset of alarming side effects.
While many of these side effects are transitory and will decrease as the drug is discontinued, some, depending on overall health and wellness and genetic predispositions as well as undiagnosed conditions, may experience not only severe side effects, but potentially long-term damage to organs and organ function.